Frank McCollum has a robust background in healthcare and agriculture. He spent two decades as a nurse before managing his family's farm, the last Grade A Dairy in Greenwood County, which involved three generations. McCollum currently raises commercial beef cattle and cultivates soybeans, milo, corn, and hay. His leadership extends to running the farm alongside his brother, niece, and her husband.

Frank McCollum's political identity is shaped by a blend of pragmatic localism and principled idealism, often combining unexpected policy stances that challenge conventional wisdom. McCollum's deep-rooted connection to Greenwood County's agricultural heritage informs his unique approach to policy, particularly in advocating for regional industrial interests while opposing corporate consolidation in food production. His legislative record reveals a surprising convergence with opposing factions on environmental regulations, showcasing an ideologically agile strategy. McCollum's rhetoric emphasizes the importance of de-escalating geopolitical conflicts to stabilize fuel costs and advocates for breaking up agricultural monopolies to lower food prices, illustrating a calculated yet unconventional policy framework.